Vascular Responses to Hypoxia and Ischemia
نویسندگان
چکیده
منابع مشابه
Vascular responses to hypoxia and ischemia.
Blood vessels function as conduits for the delivery of O(2) and nutrients. Hypoxia-inducible factor 1 (HIF-1) mediates adaptive transcriptional responses to hypoxia/ischemia that include expression of angiogenic cytokines/growth factors by hypoxic cells and expression of cognate receptors for these ligands by vascular cells and their progenitors. Impairment of HIF-1-dependent responses to hypox...
متن کاملHIF and pulmonary vascular responses to hypoxia.
In the lung, acute reductions in oxygen lead to hypoxic pulmonary vasoconstriction, whereas prolonged exposures to hypoxia result in sustained vasoconstriction, pulmonary vascular remodeling, and the development of pulmonary hypertension. Data from both human subjects and animal models implicate a role for hypoxia-inducible factors (HIFs), oxygen-sensitive transcription factors, in pulmonary va...
متن کاملHIGHLIGHTED TOPIC Hypoxia HIF and pulmonary vascular responses to hypoxia
Shimoda LA, Laurie SS. Hif and pulmonary vascular responses to hypoxia. J Appl Physiol 116: 867– 874, 2014. First published December 12, 2013; doi:10.1152/japplphysiol.00643.2013.—In the lung, acute reductions in oxygen lead to hypoxic pulmonary vasoconstriction, whereas prolonged exposures to hypoxia result in sustained vasoconstriction, pulmonary vascular remodeling, and the development of pu...
متن کاملEffect of hypoxia on vascular responses to the carotid baroreflex.
The effect of systemic hypoxia on the vascular responses to the carotid baroreflex was studied in anesthetized, vagotomized, artificially ventilated dogs. One hindlimb, kidney, gracilis muscle, and paw were perfused at constant flow, and neurograms were obtained from renal sympathetic fibers. Bilateral carotid occlusions were performed while the animal was breathing a mixture of air and O2 (mea...
متن کاملPulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1.
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls transcriptional responses to hypoxia. HIF-1 plays critical roles both during development and in response to physiologic and pathophysiologic stimuli in the adult. Here, the involvement of HIF-1 in lung pathophysiology will be discussed.
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2010
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.108.181644